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KMID : 0616620000060020385
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Journal of Soonchunhyang Medical College
2000 Volume.6 No. 2 p.385 ~ p.390
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4G/5G Polymorphism of the PAI-1 Gene in Cerebral Infarction
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Abstract
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Background : Decreased fibrinolysis due to increased plasminogen activator inhibitior-1 (PAI-1) activity has been associated with hypertension or cerebral infarction. The aims of this study were to observe associations of the genetic polymorphism for PAI-1 with hypertension and cerebral infarction, and to elucidate whether impaired fibrinolytic activity in cerebral infarction was related to atherothrombosis or to risk factors such as hypertension.
Methods : Patients with cerebral infarction (n=60), hypertension (n=100), and control subjects (n=100) were enrolled. We genotyped all subjects for 4G/5G polymorphism in the promoter region of the PAI-1 gene.
Results : The frequency of 4G/4G genotype of PAI-1 was significantly higher in the patients of cerebral infarction than the control subjects (41.7% versus 21.0%, p=0.005), but not in the hypertensive subjects. There was a significant association between 4G/4G genotypes of PAI-1 and cerebral infarction (adjusted odds ratio=3.11, 95% confidence interval, 1.18-8.15), adjusting for age, sex, total cholesterol, low-density lipoprotein, triglyceride, and body mass index.
Conclusion : Our results suggest that the 4G/4G genotype of the PAI-1 gene is significantly associated with an increased risk of cerebral infarction.
Key Words : Cerebral infarction, Hypertension, PAI-1, Genetic polymorphism
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